Changing enzyme specificity

S. Tomic
R. Boskovic Institute, Zagreb, Croatia

I will present the enzyme problem in general, give a few examples of diseases correlated with (inadequate) specificity of enzymes, introduce lipases as enzymes that stereoselectively catalyse reactions, stress importance of such catalysis for production of drugs, explain how stereoselectivity could be changed (and reversed), and how we approach this problem by molecular modeling.