We discuss some of the major issues in particle physics to be addressed in the coming years, in particular with the advent of the Large Hadron Collider (LHC) project at CERN. We present the present status of the machine, of the major experiments, more specifically of the general purpose CMS (Compact Muon Solenoid) experiment, with the prospects for Higgs boson searches, for electroweak scale Supersymmetry and CP violation studies in the B sector.